Correlation between neonatal vitamin D level and maternal vitamin D level.
- Author:
Chen WANG
1
;
Jin-Song GAO
;
Song-Lin YU
;
Ling QIU
;
Lin ZENG
;
Dan-Hua WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Humans; Infant, Newborn; Male; Pregnancy; blood; ROC Curve; Vitamin D; analogs & derivatives; blood; Vitamin D Deficiency; diagnosis
- From: Chinese Journal of Contemporary Pediatrics 2016;18(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between neonatal and maternal vitamin D levels.
METHODSFrom June 1 to July 10, 2015, umbilical venous blood samples were collected from 102 full-term single neonates, and venous blood samples were collected from their mothers. Ultra-performance liquid chromatography with isotope dilution was applied to measure the serum 25(OH)D level.
RESULTSVitamin D insufficiency was found in 39 mothers (38.2%) and 27 neonates (26.5%), and vitamin D deficiency was found in 25 mothers (24.5%) and 66 neonates (64.7%). Neonatal serum 25(OH)D level differed significantly between the groups of mothers with different serum 25(OH)D levels (P<0.001). Maternal 25(OH)D level was positively correlated with neonatal vitamin D level (r=0.914, P<0.001). When the receiver operating characteristic curve for maternal 25(OH)D level was used to predict neonatal vitamin D deficiency (≤15 ng/mL), the area under the curve was 0.962 (95%CI: 0.930-0.994; P<0.001). The sensitivity and specificity of maternal serum 25(OH)D level≤27.55 ng/mL to predict neonatal vitamin D deficiency were 97.2% and 80.3%, respectively.
CONCLUSIONSNeonatal vitamin D level is positively correlated with maternal vitamin D level. Maternal vitamin D level can help to predict neonatal vitamin D deficiency.
