The association between IL-1 gene polymorphisms and susceptibility to severe periodontitis.
- Author:
Haiyan DUAN
1
;
Jincai ZHANG
;
Yunhui ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Female; Genetic Predisposition to Disease; genetics; Humans; Interleukin-1; genetics; Male; Middle Aged; Periodontitis; genetics; metabolism; Polymorphism, Restriction Fragment Length
- From: West China Journal of Stomatology 2002;20(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe purpose of this study was to investigate the relationship between IL-1 gene polymorphisms and susceptibility to severe periodonitis in Chinese of the Han Nationality.
METHODSDNA samples with buccal swabs were collected from 30 patients with severe adult periodontitis (AP), 20 patients with rapid progressive periodontitis (RPP) and 94 healthy control (HC) individuals. Polymorphisms in the IL-1 gene cluster were analyzed with PCR-RFLP.
RESULTSIt was found that the frequency of IL-1B + 3953/Taq I allele 2 was significantly higher in severe AP patients (OR = 6.8, P < 0.05) and RPP patients (OR = 9.6, P < 0.05) than in healthy controls, and the frequency of IL-1RN intron II/VNTR allele 2 was significantly higher in the group of severe AP patients (OR = 6.3, P < 0.05) than in the group of healthy controls.
CONCLUSIONIL-1B + 3953/Taq I allele 2 and IL-1RN nitrol IL/VNTR allele 2 are genetic indicators of susceptibility to severe AP and RPP, and both AP and RPP are genetic heterogeneous.
