Effects of exogenous IL-10 on IL-6 and ICAM-1 expression in inflammatory gingival tissue.
- Author:
Pishan YANG
1
;
Xiangmin QI
;
Shaohua GE
;
Min ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Down-Regulation; Female; Gingiva; metabolism; Gingivitis; metabolism; Humans; Intercellular Adhesion Molecule-1; biosynthesis; genetics; Interleukin-10; pharmacology; Interleukin-6; biosynthesis; genetics; Male; Middle Aged
- From: West China Journal of Stomatology 2002;20(5):343-345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study aimed at investigating effects of exogenous interleukine-10 (IL-10) on IL-6 and intercellular adhesion molecular (ICAM-1) expression in inflamed gingival tissue.
METHODSThe expression of IL-6 and ICAM-1 was examined using immunohistochemical techniques. Inflammatory gingival tissue treated with IL-10 was taken as the experimental group and the same patient's inflammatory gingival tissue without treatment of IL-10 was included into the control group.
RESULTSIL-6 expression was found mainly in monocytes, macrophages, lymphocytes, endotheliocytes and fibroblasts. The expression of ICAM-1 was found mainly in epithelial cells, monocot-macrophages, lymphocytes, endotheliocytes and fibroblasts. The immunohistochemical optical density (IOD) of the expression of IL-6 and ICAM-1 was detected by using Image-Proplus software, and the results showed that the expression in the experimental group differed significantly from that in the control group.
CONCLUSIONThe exogenous IL-10 may down-regulate IL-6 and ICAM-1 expression in inflammatory gingival tissue.
