Serial pathologic changes in livers of Tree shrews and Macaca assamensises infected with human Hepatitis B virus.
- Author:
Shu-sheng WANG
1
;
Jian-jia SU
;
Bai-fang FENG
;
Yuan LI
;
Tao ZHANG
;
Liu-liang QIN
;
Guo-yong HUANG
;
Jian-en GAO
;
Xian-min GE
;
He-min LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antibodies, Viral; immunology; Disease Models, Animal; Female; Hepatitis B; immunology; pathology; virology; Hepatitis B virus; immunology; physiology; Humans; Liver; pathology; virology; Macaca; Male; Tupaiidae
- From: Chinese Journal of Experimental and Clinical Virology 2003;17(3):244-246
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo serially observe the pathologic changes in livers of tree shrews and macaca assamensises infected with HHBV.
METHODS10 adult tree shrews and 28 macaca assamensises were inoculated with HBV rich human sera. The liver of the animals were regularly biopsied. The liver samples were examined histopathologically by HE staining. Some samples were stained for HBsAg by immunohistochemistry (IH), and HBV DNA by in situ hybridization (ISH).
RESULTSHBsAg in 80% of tree shrews infected with HHBV can be detected by IH, HBV DNA in 50% of those can be found by ISH.The positive rates of HBsAg in macaca assamensises' livers were 25% by IH, none HBV DNA was detected.
CONCLUSIONThe tree shrew model seems to be applicable for the research of human hepatitis B.
