Advances of taxol combinatorial biosynthesis.
- Author:
Jie LI
;
Chunmei WANG
- Publication Type:Journal Article
- MeSH:
Biotechnology;
trends;
Bryopsida;
metabolism;
Fermentation;
Genetic Engineering;
Paclitaxel;
biosynthesis
- From:
Chinese Journal of Biotechnology
2014;30(3):355-367
- CountryChina
- Language:Chinese
-
Abstract:
Taxol is a kind of isoprenoid with strong anticancer activity. It is difficult to be obtained because of its low concentration in nature, which hinders its application in cancer treatment. Recently, biosynthesis methods for taxol production have attracted more attentions. Several systems including Escherichia coli, Saccharomyces cerevisiae, Physcomitrella patens, Arabidopsis, tomato and ginseng were explored. This review focuses on the advance in biosynthesis of taxol in different systems and features the bottleneck of scale fermentation for producing the intermediates. At the same time some advices for the further were given. At last, the future and character of Physcomitrella patens system used in taxol combinatorial biosynthesis were analyzed based on our lab's research.
