Chemical constituents of bear bile.
- Author:
Qiang LUO
1
;
Quancheng CHEN
;
Yao WU
;
Miaomiao JIANG
;
Zhihong CHEN
;
Xiaokun ZHANG
;
Haifeng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bile; chemistry; Gallbladder; chemistry; Medicine, Chinese Traditional; Ursidae; metabolism
- From: China Journal of Chinese Materia Medica 2010;35(18):2416-2419
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents of bear bile.
METHODThe compounds were isolated by repeated column HP20 macroporous adsorption resin, Sephadex LH-20, ODS and silica gel as packing materials. The structures were identified on the basis of extensive spectroscopic data analysis and by comparison of their spectral data reported.
RESULTNine compounds were identified as 4',7-dihydroxyisoflavone (1), 4',7-dihydroxy-6-methoxyisoflavone (2), 4',6,7-trihydroxyisoflavone (3), 4'-methoxy-7-hydroxyisoflavone (4), tauroursodeoxycholic acid (5), taurochenodeoxycholic acid (6), ursodeoxycholic acid (7), chenodeoxycholic acid (8), cholesterol (9).
CONCLUSIONCompounds 1-4 were separated from bear bile for the first time.
