The inhibition activity of chemical constituents in hawthorn fruit and their synergistic action to HMG-CoA reductase.
- Author:
Wenwen HUANG
1
;
Xiaoli YE
;
Xuegang LI
;
Zhongqi ZHAO
;
Ping LAN
;
Liang WANG
;
Ming LIU
;
Ying GAO
;
Jiaying ZHU
;
Ping LI
;
Ping FENG
Author Information
- Publication Type:Journal Article
- MeSH: Crataegus; chemistry; Fruit; chemistry; Hydroxymethylglutaryl CoA Reductases; analysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; pharmacology; Plant Extracts; pharmacology
- From: China Journal of Chinese Materia Medica 2010;35(18):2428-2431
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the hypolipidemic active compounds from Crataegus pinnatifida and mechanism of action of those.
METHODGuided by the inhibitory activity to HMG-CoA reductase, the active compounds were separated and purified with macroporous resin and silica gel.
RESULTFour active compounds were obtained, which were quercetin, hyperoside, rutin and chlorogenic acid, the sum of their inhibitory rate was 50.01%, and the total inhibitory rate of the mixture of four active compounds matched was 79.48%.
CONCLUSIONQuercetin and hyperoside were the principle active components inhibiting HMG-CoA reductase in Hawthorn fruit, and there were synergistic action among them.
