Preparation and characterization of non-ionic surfactant vesicle of cantharidin.
- Author:
Hui LI
1
;
Qingying FANG
;
Hong ZHANG
;
Chen ZANG
;
Baoxian ZHANG
;
Qixia NIE
;
Guohua WANG
Author Information
- Publication Type:Journal Article
- MeSH: Cantharidin; administration & dosage; chemistry; isolation & purification; Chromatography, High Pressure Liquid; Drug Delivery Systems; Liposomes; administration & dosage; chemistry; Particle Size; Surface-Active Agents; administration & dosage
- From: China Journal of Chinese Materia Medica 2010;35(19):2546-2550
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preparation of cantharidin entrapped non-ionic surfactant vesicle (noisome)and evaluate its quality.
METHODThe niosome loaded with cantharidin was prepared using injection method by non-ionic surfactants as the carrier. An centrifugation separation method and HPLC analysis method of the cantharidin were established to detect the entrapment efficiency. The optimum preparation technology was established by a orthogonal experiment. The morphology, and particle size were studied to evaluate the preparation.
RESULTThe average size of niosomes were (209. 8 +/- 0.5) nm. The entrapment efficiency of the CTD-NS was (27.5% +/- 2.0%) and Zeta potential was (41.5 +/- 0.65) mV.
CONCLUSIONThe preparation of cantharidin noisome by TweenA and SpanB is practicable and successful. These experiments can be the basement of developing targeting drug delivery system.
