Alkaloids from Senecio scandens.
- Author:
Daopeng TAN
1
;
Ying CHEN
;
Lili JI
;
Guixin CHOU
;
Zhengtao WANG
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; chemistry; Alkaloids; chemistry; isolation & purification; pharmacology; Animals; Cell Proliferation; drug effects; Cells, Cultured; Chromatography, High Pressure Liquid; methods; Dextrans; chemistry; Hepatocytes; Lactones; isolation & purification; metabolism; pharmacology; Mice; Mice, Inbred ICR; Pyrrolizidine Alkaloids; isolation & purification; metabolism; pharmacology; Senecio; chemistry; Silica Gel; Tyramine; analogs & derivatives; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2010;35(19):2572-2575
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the alkaloids from Senecio scandens.
METHODCompounds were isolated with silica gel and Sephadex LH-20 column chromatography and their structures were determined by spectral analysis and chemical evidence. The hepatic cytotoxicity of isolated compounds was tested by MTT method in vitro.
RESULTSix alkaloids were obtained and identified as adonifoline (1), 7-angeloylturneforcidine (2), hordenine (3), 1, 3, 6, 6-tetramethyl-5, 6, 7, 8-tetrahydro-isoquinolin-8-one (4), 4-(pyrrolidin-2-one) -phenyl acetic acid (5), (4-pyrrolidinophenyl) acetic acid (6).
CONCLUSIONCompound 6 is a new natural product, compounds 3, 4 were obtained from the genus Senecio for the first time, compounds 2, 5 were obtained from this plant for the first time. Compound 1 showed significant growth inhibitory effect against hepatocyte at 100 micromol x L(-1).
