Microdialysis and HPLC method for determination of concentration of pantoprazole in rat striatum aftercombined administration with borneol.
- Author:
Yuning WEI
1
;
Ping LIU
;
Xinrong HE
;
Qin CHEN
Author Information
- Publication Type:Journal Article
- MeSH: 2-Pyridinylmethylsulfinylbenzimidazoles; pharmacokinetics; Animals; Blood-Brain Barrier; Bornanes; pharmacology; Ceftriaxone; pharmacology; Chromatography, High Pressure Liquid; Corpus Striatum; drug effects; metabolism; Drug Combinations; Male; Medicine, Chinese Traditional; Microdialysis; Neostriatum; drug effects; metabolism; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2010;35(19):2605-2608
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the influence of borneol, a traditional Chinese medicine, on the concentration of ceftriaxone in the rat brain striatum and evaluate the relativity.
METHODThe sample of cerebrospinal fluid in the rat brain striatum was collected via brain microdialysis technology, and then the contents of ceftriaxone in standard preparation and sample were detected by high efficiency liquid chromatography combined with diode array detector respectively and analyzed statistically. The concentration of ceftriaxone in rat brain striatum in the ceftriaxone + Borneol group was compared with that in the ceftriaxone-only group.
RESULTThe concentration of ceftriaxone in the rat brain in the ceftriaxone + Borneol group (13.01-4.43 mg x L(-1)) is significantly higher than that in the ceftriaxone-only group (2.41-0.94 mg x L(-1)).
CONCLUSIONBorneol can promote ceftriaxone through blood-brain barrier, and increase the concentration thereof in striatum.
