Study on excretion of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion.
- Author:
Xiaoliang REN
1
;
Huizi OUYANG
;
Guifang WANG
;
Min ZHAO
;
Aidi QI
Author Information
1. College of Traditional Chinese Medicine, TianJin University of Traditional Chinese Medicine, Tianjin 300193, China.
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Bile;
metabolism;
secretion;
Biological Transport;
physiology;
Chromatography, High Pressure Liquid;
methods;
Feces;
Glycosides;
chemistry;
Inclusion Bodies;
secretion;
Injections, Intravenous;
Male;
Rats;
Rats, Sprague-Dawley;
Stilbenes;
administration & dosage;
chemistry;
beta-Cyclodextrins;
metabolism
- From:
China Journal of Chinese Materia Medica
2010;35(19):2620-2623
- CountryChina
- Language:Chinese
-
Abstract:
The excretion characteristics of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion in bile, urine and feces after oral administration to rats were studied. Bile for 24 h, urine and feces for 72 h were collected. The content of THSG was determined by HPLC-UV. The established HPLC-UV method was available for the analysis of THSG in excreta and corresponded to the requirement of biological sample analysis. After given THSG and its beta-cyclodextrin inclusion, the amount of prototype THSG in feces were 3.27% and 0.61%, meanwhile THSG in bile were 0.20% and 0.18%, respectively. Only a little THSG was found in urine. The result showed that beta-cyclodextrin inclusion reduced the fecal excretion of THSG. However, the characteristic of urinary and biliary excretion wasn't changed.
