Effect of processing on metabolism of amygdalin from bitter almond in rat.
- Author:
Minfeng FANG
1
;
Zhiling FU
;
Qilin WANG
;
Shixiang WANG
;
Chaoni XIAO
;
Xiaohui ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Amygdalin; analysis; metabolism; Animals; Female; Male; Prunus; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2010;35(20):2684-2688
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of processing on metabolism of the main component of bitter almond-amygdalin in rat.
METHODThe blood was collected at different times after amygdalin given by injection and oral, bitter almond and its processed production given by oral respectively, and then detected by both HPLC and HPLC-MS(n) methods after extraction pretreatment.
RESULTAfter injection, amygdalin was absorbed in prototype to blood rapidly, while the other three kinds of medicine given by oral were all not detected the prototype of amygdalin, but two metabolites were detected which were isomers of prunasin confirmed by mass spectrometry. The metabolic pathway of prunasin in processed bitter almond group was markedly different from the bitter almond group.
CONCLUSIONProcessing has a significant effect on bitter almond metabolic processes in rats.
