Influence of regulatory peptides on the secretion of interleukins from bronchial epithelial cells of the rabbit.
- Author:
Yu-Rong TAN
1
;
Xiao-Qun QIN
;
Cha-Xiang GUAN
;
Chang-Qing ZHANG
;
Yang XIANG
;
Yan-Hong REN
Author Information
1. Department of Physiology, XiangYa Medical College, Central South University, Changsha 410078.
- Publication Type:Journal Article
- MeSH:
Animals;
Bronchi;
cytology;
Calcitonin Gene-Related Peptide;
pharmacology;
Cells, Cultured;
Endothelin-1;
pharmacology;
Epidermal Growth Factor;
pharmacology;
Epithelial Cells;
drug effects;
secretion;
Female;
Interleukins;
secretion;
Male;
Rabbits;
Vasoactive Intestinal Peptide;
pharmacology
- From:
Acta Physiologica Sinica
2002;54(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
To explore the role of regulatory peptides in the secretion of bronchial epithelial cells (BECs), we observed the effects of four peptides, i.e.vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP), on the secretion of ILs from unstimulated or O3-stressed BECs. The results of the experiments showed that VIP exerted an inhibitory effect on the secretion of IL-1 and IL-8 from unstimulated and O3-stressed BECs, VIP also decreased the secretion of IL-5 from O3-stressed BECs; EGF promoted secretion of IL-1 and IL-8 from unstimulated BECs, but decreased the secretion of ILs from O3-stressed BECs; ET-1 and CGRP enhanced the secretion of IL-1, IL-5, and IL-8 from unstimlated BECs, CGRP also increased the secretion of ILs from O3-stressed BECs. The results obtained demonstrate that intrapulmonary regulatory peptides modulate the secretion of ILs from BECs, and may play an important part in transduction of inflammatory signals.
