Protective effects of paraventricular nucleus stimulation and vasopressin on gastric ischemia-reperfusion injury in rats.
- Author:
Jian-Fu ZHANG
1
;
Yong-Mei ZHANG
;
Chang-Dong YAN
;
Xiu-Ping ZHOU
;
You-Jian QI
Author Information
1. Department of Physiology, Xuzhou Medical College Xuzhou 221002. zjf_xz@sina.com
- Publication Type:Journal Article
- MeSH:
Afferent Pathways;
physiology;
Animals;
Electric Stimulation;
Male;
Paraventricular Hypothalamic Nucleus;
drug effects;
physiology;
Rats;
Rats, Sprague-Dawley;
Reperfusion Injury;
physiopathology;
therapy;
Stimulation, Chemical;
Stomach;
blood supply;
Sympathetic Nervous System;
physiology;
Vagus Nerve;
physiology;
Vasopressins;
pharmacology
- From:
Acta Physiologica Sinica
2002;54(2):133-138
- CountryChina
- Language:Chinese
-
Abstract:
The effects of paraventricular nucleus (PVN) stimulation and vasopressin on gastric ischemia-reperfusion injury (GI-RI) were investigated in male SD rats of which the celiac artery was clamped for 30 min and reperfused for 1 h by removal of the clamp. The results were as follows. Both electrical and chemical stimulation of the PVN obviously attenuated the GI-RI. Bilateral electrolytic lesion of the nucleus tractus solitarius (NTS) or microinjection of AVP-V(1) receptor antagonist into the NTS could eliminate the protective effect of electrical stimulation of the PVN on GI-RI. Hypophysectomy did not influence the effect of electrical stimulation of the PVN. Both vagotomy and sympathectomy could increase the effect of stimulating PVN on GI-RI. Microinjection of arginine-vasopressin (AVP) into the PVN also attenuated the effect on GI-RI. These results suggest that the PVN and AVP participate in the regulation of GI-RI and play an important role in protection against GI-RI. This protective effect of PVN on GI-RI might be mediated by activation of AVP-ergic neurons in the PVN, which release AVP from the descending projection fibers and activate the AVP-V(1) receptors on the NTS neurons. The vagus and sympathetic nerves are involved in the efferent pathway exerting their effects on GI-RI. Hypophysis does not seem to be involved in the protective effect of PVN stimulation.
