Effect of angiotensin II on potassium channels of ischemic ventricular myocytes of the guinea pig.
- Author:
Wen-Wei WANG
1
;
Yi-Chun ZHU
;
Tai YAO
;
Ping ZHENG
;
Qian-Ling GONG
Author Information
1. Department of Physiology, Medical Center of Fudan University, Shanghai 200032. wangwenwei66@yahoo.com
- Publication Type:Journal Article
- MeSH:
Angiotensin II;
pharmacology;
Animals;
Cells, Cultured;
Female;
Guinea Pigs;
Heart Ventricles;
cytology;
drug effects;
Male;
Myocardial Ischemia;
pathology;
physiopathology;
Myocytes, Cardiac;
drug effects;
Potassium Channels;
drug effects;
physiology
- From:
Acta Physiologica Sinica
2002;54(2):149-153
- CountryChina
- Language:Chinese
-
Abstract:
The experiments were carried out on guinea pig isolated ventricular myocytes by using whole-cell patch clamp. The effects of angiotensin II (Ang II) on potassium ion channels of acute ischemic myocytes were observed. Whole-cell patch clamp recordings showed that physiological potassium current, including delayed rectifier potassium current and inward rectifier potassium current were inhibited under the condition of simulated ischemia, and then further inhibited by treatment with Ang II. ATP-sensitive potassium currents were increased under simulated ischemia and were further enhanced by Ang II treatment.
