Effect of SO2 derivatives on sodium currents in acutely isolated rat hippocampal CA1 neurons.
- Author:
Zi-Qiang MENG
1
;
Nan SANG
Author Information
1. Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006, China. zqmeng@sxu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Dose-Response Relationship, Drug;
Female;
Hippocampus;
cytology;
drug effects;
Male;
Membrane Potentials;
drug effects;
Neurons;
drug effects;
physiology;
Patch-Clamp Techniques;
Rats;
Rats, Wistar;
Sodium Channels;
drug effects;
physiology;
Sulfites;
toxicity
- From:
Acta Physiologica Sinica
2002;54(3):267-270
- CountryChina
- Language:Chinese
-
Abstract:
The effect of SO2 derivatives on Na(+) currents was studied in freshly dissociated hippocampal CA1 neurons of rat using the whole-cell patch-clamp technique. The results indicated that SO2 derivatives caused a dose-dependent and voltage-dependent increase in the voltage-activated Na+ currents. The amplitudes of Na(+) currents were increased by 50.59 19.08% and 82.06 18.51% (n=15)by SO2 derivatives at 10 and 100 micromol/L, respectively. The action was frequency-independent. The results also showed that SO2 derivatives did not affect the activation process, but changed the inactivation process significantly. Before and after application of 10 micromol/L SO2 derivatives, the half-inactivation voltage was -69.71+/-4.67 and -53.27+/-4.95 mV (n=10, P<0.01), respectively, but the slope factor was not changed. These results imply that SO2 derivatives have neurotoxic effects and that SO2 pollution is probably related to some diseases of central neuronal system.
