Effect of ginsenoside total saponinon on regulation of P450 of livers of rats after γ-ray irradiation.
- Author:
Jian-feng YI
;
Bo WU
;
Cang-long LIU
;
Yue GAO
- Publication Type:Journal Article
- MeSH:
Animals;
Cytochrome P-450 Enzyme System;
genetics;
metabolism;
Drugs, Chinese Herbal;
pharmacology;
Gamma Rays;
Ginsenosides;
pharmacology;
Liver;
drug effects;
enzymology;
radiation effects;
Male;
Microsomes, Liver;
drug effects;
enzymology;
Panax;
chemistry;
Rats;
Rats, Wistar
- From:
China Journal of Chinese Materia Medica
2015;40(20):4037-4043
- CountryChina
- Language:Chinese
-
Abstract:
Effect of ginsenoside total saponin (GTS) on the regulation of P450 of livers of rats after γ-ray irradiation was studied. Rats were irradiated by the ⁶⁰Coγ-ray for one-time dose of 5.5 Gy, dose rate of 117.1-119.2 cGy. The cocktail probe, qPCR and Western blot were used to detect expression of enzymatic activites, mRNA and protein of rats. Contrasted with blank group, expression of CYP1A2, 2B1, 2E1, 3A4 of irradiation group showed a up-regulated (P < 0.05). Contrasted with irradiation group, exprression of CYP1A2, 2B1, 2E1, 3A4 of GTS group showed a downward trend. GTS had negative agonistic action against expression of P450 of rats by irradiatied.
