Comparison of total phenol of magnolia solid dispersion prepared by different methods.
- Author:
Jie LI
;
Liu-qing DI
;
Jun-song LI
;
An KANG
;
Jing QIAN
;
Deng-jie WANG
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
methods;
Drugs, Chinese Herbal;
chemistry;
Magnolia;
chemistry;
Phenol;
chemistry;
Spectroscopy, Fourier Transform Infrared;
X-Ray Diffraction
- From:
China Journal of Chinese Materia Medica
2015;40(22):4400-4405
- CountryChina
- Language:Chinese
-
Abstract:
To compare the difference of total phenol of magnolia solid dispersion prepared by different methods. Hot melt extrusion, solvent evaporation method, and fusion-cooling method were used to prepare total phenol of Magnolia accessory solid dispersion, Plastone S-630 and HPC. The drug dispersion state in the prepared solid dispersion was evaluated with DSC and X-ray diffraction; FT-IR method was used to analyze the possible connections between drug and accessories. Finally, accelerated stability-in vivo dissolution test was use to compare the stability differences between these three processes. The results of DSC and X-ray diffraction showed that all of the drug in solid dispersion processed by three processes can exist in amorphous form; FT-IR results also could not distinguish the difference between the three processes; accelerated stability-in vivo dissolution test showed the stability of solid dispersion prepared by HPC was better than Plastone S-630, and the same kinds of materials solid dispersion prepared by hot melt extrusion showed a better stability than the other two processes.
