Optimization of one-step pelletization technology of Biqiu granules by Plackett-Burman design and Box-Behnken response surface methodology.
- Author:
Yan-jun ZHANG
;
Li-li LIU
;
Jun-hua HU
;
Yun WU
;
En-xiang CHAO
;
Wei XIAO
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
methods;
Drugs, Chinese Herbal;
chemistry;
Temperature
- From:
China Journal of Chinese Materia Medica
2015;40(22):4406-4410
- CountryChina
- Language:Chinese
-
Abstract:
First with the qualified rate of granules as the evaluation index, significant influencing factors were firstly screened by Plackett-Burman design. Then, with the qualified rate and moisture content as the evaluation indexes, significant factors that affect one-step pelletization technology were further optimized by Box-Behnken design; experimental data were imitated by multiple regression and second-order polynomial equation; and response surface method was used for predictive analysis of optimal technology. The best conditions were as follows: inlet air temperature of 85 degrees C, sample introduction speed of 33 r x min(-1), density of concrete 1. 10. One-step pelletization technology of Biqiu granules by Plackett-Burman design and Box-Behnken response surface methodology was stable and feasible with good predictability, which provided reliable basis for the industrialized production of Biqiu granules.
