A new isoindole alkaloid from leaves of Cassia siamea.
- Author:
Ling ZHOU
1
;
Wei DONG
1
;
Yue-de WANG
1
;
Kun ZHOU
1
;
Hang-Ying MA
1
;
Yan YANG
1
;
Huan-Huan XING
1
;
Min ZHOU
1
;
Qiu-Fen HU
1
;
Yan-Qing YE
1
Author Information
- Publication Type:Journal Article
- Keywords: Cassia siamea; Dai drug; cytotoxicity; isoindole alkaloid
- From: China Journal of Chinese Materia Medica 2016;41(9):1646-1648
- CountryChina
- Language:Chinese
- Abstract: A new isoindole alkaloid (1), has been isolated from the leaves of Cassia siamea by using various chromatographic techniques. Compound 1 is a new compound, determined as 5-(hydroxymethyl)-2-methyl-6-prenylisoindolin-1-one, and it displayed cytotoxicity against NB4, A549, SHSY5Y, PC3 and MCF7 cell lines with IC₅₀ values of 3.2,4.6,2.8,6.4, 2.5 μmol•L⁻¹, respectively.
