Study of diffusion of muscone in different inclusion complexes and liposome through mouse (correction of rat) skin in vitro.
- Author:
Liu-qing DI
1
;
Chun-qin MAO
;
Hui XIE
;
Rong GUO
;
Ming XUE
;
Ke YAN
;
Li ZHANG
;
Hong-yan LI
Author Information
- Publication Type:Journal Article
- MeSH: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cycloparaffins; administration & dosage; pharmacokinetics; Drug Carriers; Drug Stability; In Vitro Techniques; Liposomes; Mice; Skin Absorption; beta-Cyclodextrins
- From: China Journal of Chinese Materia Medica 2005;30(4):260-263
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the penetrating rate of muscone in different inclusion complexes and liposome.
METHODThe transdermal effect of muscone in different inclusion complexes and liposome was studied comparatively on mouse [corrected] skin with 40% EtOH as the absorption solution and with an improved Franz diffuse cell.
RESULTAmong the different inclusion complexes and liposome, the penetrating rate of muscone in the HP-beta-cyclodextrin inclusion and the liposome were higher than muscone, and that of muscone in the beta-cyclodextrin inclusion is the lowest.
CONCLUSIONThe HP-beta-cyclodextrin inclusion and the liposome can hence the muscone transdermal speed.
