Studies on dissolution rate in vitro of silymarin dropping pill.
- Author:
Xia SUN
1
;
Ming-feng QIU
;
Shao-shun LI
;
Jian-xin WANG
;
Qi SHEN
;
Wei JIA
Author Information
- Publication Type:Journal Article
- MeSH: Capsules; Drugs, Chinese Herbal; administration & dosage; chemistry; Silymarin; administration & dosage; chemistry; Solubility; Spectrophotometry, Ultraviolet; Tablets
- From: China Journal of Chinese Materia Medica 2005;30(4):263-265
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo test the dissolution rate of silymarin dropping pill as well as to be compared with other three commercial products of the silymarin.
METHODBy UV spectrophotometry, we studied the dissolution conditions of silymarin dropping pill and compared its dissolution rate with Yiganling tablets (film-coating, sugar-coating) and Legalon capsule which are available in the market.
RESULTThe dissolution parameters T50 and Td of silymarin dropping pill, Yiganling tablet (film-coating), Yiganling tablet (sugar-coating) and Legalon capsule are 6.78, 9.85 min, 51.01, 73.78 min, 74.35, 86.97 min and 53.10, 72.65 min.
CONCLUSIONThe dissolution rate of silymarin dropping pill is superior to that of two kinds of Yiganling tablets and Legalon capsule.
