Histopathological study on allergic rhinitis treated with Centipeda minima.
- Author:
Zhi-gang LIU
1
;
Hong-mong YU
;
Shan-li WEN
;
Yu-ling LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Asteraceae; chemistry; Epithelium; ultrastructure; Female; Guinea Pigs; Lysosomes; drug effects; Male; Mitochondrial Swelling; drug effects; Nasal Mucosa; pathology; ultrastructure; Oils, Volatile; isolation & purification; pharmacology; Phytotherapy; Plants, Medicinal; chemistry; Rhinitis, Allergic, Seasonal; drug therapy; pathology
- From: China Journal of Chinese Materia Medica 2005;30(4):292-294
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of this study was to investigate the mechanisms of C. minima in the treatment of allergic rhinitis.
METHODAn allergic rhinitis animal model induced by ragweed pollen was established. After treatment with an active extract of C. minima, histopathological changes in the nasal mucosa of guinea pig were observed by transmission electron microscope.
RESULTIn the allergeic rhinitis model group, there appear a large number of lysosomes in the nasal epithelium with organelles vacuolated and nucleus deformed. Cells in the proper lamina of connective tissue were disarranged with organelles damaged, and there was also infiltration of eosinophils and mast cells in the connective tissue. However, in the treatment group receiving C. minima extract, the pathological changes mentioned above were significantly decreased.
CONCLUSIONC. minima is effective in treating allergic rhinitis.
