Different mechanisms mediated the potentiation uterine smooth muscle caused by Polygala tenuifolia decoction progesterone in virginal rats.
- Author:
Jing-dong XU
1
;
Wen WANG
;
Xiao-min QIN
Author Information
- Publication Type:Journal Article
- MeSH: Adrenergic alpha-Antagonists; pharmacology; Animals; Calcium Channels, L-Type; drug effects; Cyclooxygenase Inhibitors; pharmacology; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Histamine H1 Antagonists; pharmacology; In Vitro Techniques; Muscarinic Antagonists; pharmacology; Muscle, Smooth; drug effects; Plants, Medicinal; chemistry; Polygala; chemistry; Rats; Rats, Wistar; Uterine Contraction; drug effects
- From: China Journal of Chinese Materia Medica 2005;30(4):295-319
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the effects of Polygala tenuifolia decoction on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips of virginal rats.
METHODTo record the effects of P. tenuifolia decoction on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips of virginal rats with biolap 410 biological system. Five blocking agents were used to study their mechanisms respectively.
RESULTDifferent dosages of water extract of P. tenuifolia (0.02, 0.04, 0.08 g x kg(-1)), could significantly potentiate uterine myoelectric activity and contractile activity of virginal rats.
CONCLUSIONThe effect of P. tenuifolia on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips in rats may be mainly associated with H1 receptor, L-voltage-dependant calcium channels or prostaglandin synthese, its nothing to M receptor.
