Enhancement of thrombolytic activities of Carthamus tinctorius processed with fermentation with a bacillus sp. C2-13.
- Author:
Chen HE
1
;
Jin-Zhao
;
Zhi-hua FENG
;
Jia-feng BAI
;
Tian-li TIAN
;
Xing-yu ZHANG
;
Qi-ling SUN
Author Information
1. College of Life Science, Sichuan University, Chengdu 610064, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bacillus;
Carthamus tinctorius;
chemistry;
microbiology;
Drugs, Chinese Herbal;
isolation & purification;
pharmacology;
Female;
Fermentation;
Fibrinolysis;
drug effects;
Fibrinolytic Agents;
pharmacology;
Male;
Mice;
Partial Thromboplastin Time;
Prothrombin Time;
Rats;
Rats, Sprague-Dawley;
Thrombin Time
- From:
China Journal of Chinese Materia Medica
2005;30(5):340-343
- CountryChina
- Language:Chinese
-
Abstract:
A processing method to enhance thrombolytic effect of Carthamus tinctorius using a fermentation technology with bacillus sp. C2-13 was investigated. The fibrinolysis and anticoagulation activity of thrombolytic extracts from an optimized fermentation process was studied using a carrageenan induced mice model. The fermented extracts resulted in significantly better thrombolytic activity, suggesting that the process was promising for use in the study and preparation of nature medicines.
