Studies on constituents from the fermentation of Alternalia sp.
- Author:
Hai-long ZHANG
1
;
Li TIAN
;
Hong wei FU
;
Yue-hu PEI
;
Hui-ming HUA
Author Information
- Publication Type:Journal Article
- MeSH: Antifungal Agents; isolation & purification; pharmacology; Ascomycota; drug effects; Fermentation; Fungi; chemistry; Molecular Structure; Phenethylamines; chemistry; isolation & purification; pharmacology; Phenols; chemistry; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2005;30(5):351-353
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the metabolites of marine fungus Alternalia sp.
METHODCompounds were separated by column chromatography and their structures were elucidated by means of chemical and spectral analysis.
RESULTSix compounds were isolated from the ethyl acetate and n-butanol extracts of the fermentation of marine fungus Alternalia sp. Their structures were elucidated as p-benzyloxy-phenol ( I ), p-hydroxy phenyl ethylamine( II ), 3-hydroxymethyl-8-hydroxyl-pyrrolopiperazine-2, 5-dione ( III ), 3-isobutyl-6-secbutyl-piperazine-2, 5-dione (IV), 5alpha, 8alpha-epidioxy-ergosta-6, 22-diene-3beta-ol (V), 3beta-hydroxxy-cholesta-5-ene (VI).
CONCLUSIONCompounds I , II, III, IV have the activity of inducing morphological deformation of mycelia germinated from conidia of Pyricularia oryzae. Compounds I , II , III were isolated from the genus Alternalia for the first time.
