Study of huchang qingfei pellets on immune function in rats infected with Mycoplasma pneumoniae.
- Author:
Ji-chang LI
1
;
Wei-ming WANG
;
Hong-juan ZHANG
;
Long DONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; CD4-CD8 Ratio; Complement C3; metabolism; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Immunoglobulin G; blood; Immunoglobulin M; blood; Interleukin-2; blood; Interleukin-6; blood; Male; Plants, Medicinal; chemistry; Platycodon; chemistry; Pneumonia, Mycoplasma; blood; immunology; Rats; Rats, Wistar; Scutellaria baicalensis; chemistry; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2005;30(5):366-369
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects and mechanism of Huchang Qingfei pellets on immune function in rats infected with mycoplasma pneumoniae.
METHODA rat model of mycoplasmal pneumonia (MP) was developed in repeated intranasal infectious routes and then the humoral and cellular immunocompetences were detected by radioimmunoassay, immune-turbidimetry and flow cytometry.
RESULTThe levels of serum IgG,IgM and IL-2, IL-6 were enhinced obviously, the complement C3 and TNF-alpha were decreased and the ratio of CD4+ /CD8+ was improved significantly in the Huchang groups as compared with MP model group.
CONCLUSIONHuchang Qingfei pellets can reinforce immune function via preventing both cellular and humoral immunity from depression in the rats with MP.
