Effects of jiantai liquid on the expression of estrogen/progesterone receptors in embryo implantation dysfunction mice endometrium.
- Author:
Yan-juan LIU
1
;
Guang-ying HUANG
;
Ming-wei YANG
;
Fu-er LU
;
Ping GONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Astragalus membranaceus; chemistry; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Embryo Implantation, Delayed; drug effects; Endometrium; metabolism; Female; Loranthaceae; chemistry; Male; Mice; Mifepristone; antagonists & inhibitors; pharmacology; Plants, Medicinal; chemistry; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2005;30(5):373-376
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanism of Jiantai liquid on the endometrium development of embryo implantation dysfunction mice.
METHODThe model of embryo implantation dysfunction mice was induced by mifepristone and treated by Jiantai liquid. All animals were sacrificed on day 8 of pregnancy. Estradiol and progesterone concentrations in serum and endometrium tissue homogenates were measured by radioimmunoassay method, the endometial expressions of estrogen receptor (ER)and progesterone receptor (PR)assessed by immunohistochemical SP method.
RESULTThere were no significantly differences in the estradiol and progesterone concentrations in serum and uterus tissue homogenates among three groups( P > 0.05). Absorbency and area rate of ER, PR in model group' s gland and stroma were higher than those in model group(P < 0.05), which was similar with the control group( P > 0.05).
CONCLUSIONJiantai liquid increase the implantation rate and improve the endometrial development by increasing the expressions of ER, PR in endometrium of embryo implantation dysfunction
