The renoprotect effect of shenhua recipe on 5/6 renal ablation rats.
- Author:
Jian-jun LI
1
;
Xiang-mei CHEN
;
Yue GU
;
Ri-bao WEI
;
Suo-zhu SHI
;
Zhong YIN
Author Information
- Publication Type:Journal Article
- MeSH: Albumins; metabolism; Animals; Astragalus membranaceus; chemistry; Atractylodes; chemistry; Blood Pressure; drug effects; Cholesterol; blood; Creatinine; blood; Curcuma; chemistry; Disease Progression; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Kidney Failure, Chronic; etiology; pathology; prevention & control; Kidney Glomerulus; pathology; Male; Nephrectomy; adverse effects; methods; Plants, Medicinal; chemistry; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2005;30(5):377-381
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the reno protective effect of Shenhua recipe on the experimental model of 5/6 renal ablation.
METHOD5/6 renal ablation rats were underlying this experiment. They were administered Shenhua, irbesartan respectively by gavage during 12 weeks. Body weight, systolic blood pressure, proteinuria, Scr, BUN, total protein, albumin, Glycero and cholesterol were measured. Histologic glomenular and tubulointerstitial damage scores were measured at 12 weeks.
RESULTThe treated groups showed significantly less histologic glomerular and tubulointerstitial damage scores at 12 weeks. The plasma albumin were higher ( P < 0.05), urine protein excretion rates, serum cholesterol and creatinine were lower than in nontreated group, but arterial blood pressure was not significantly different in the three Shenhua treated groups compared with nontreated group.
CONCLUSIONShenhua can retard the progression of chronic renal injury in the 5/6 renal ablation without changes in systolic blood pressure.
