Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process.
- Author:
Feng-Xia LIU
1
;
Gang XUE
;
Qiu-Hua GAO
;
Wei-Xia GAO
;
Li-Hua ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Ethanol; Fatty Acids, Essential; chemistry; isolation & purification; Linoleic Acids; Oenothera; chemistry; Plant Oils; Plants, Medicinal; chemistry; Technology, Pharmaceutical; methods; Temperature; Urea; gamma-Linolenic Acid; administration & dosage; isolation & purification
- From: China Journal of Chinese Materia Medica 2005;30(6):433-435
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of all factors during the process of urea encapsulation of gamma-linolenic acid on the purity and yield.
METHODTo observe the material proportions, time, temperature and purity using single-factor and two-factor tests.
RESULTSingle-factor test showed that the optimal ratio of all materials (oil, urea and 95% ethanol) was 1:3:8. A 30% purity after single encapsulation process was obtained, at the best temperature range was - 15 degrees C-20 degrees C, for 24 hours. Two-factor test showed that the optimal ratio of oil, urea and ethanol was 1:3:8, where the concentration of ethanol was 90%-95%. The purity reached 90% or higher, with three-time encapsulation process.
CONCLUSIONAn optimized process was identified where material ratios, encapsulation time, temperature, and ethanol concentrations were determined using single-factor and two-factor tests.
