Protection of puerarin on the cerebral injury in the rats with acute local ischemia.
- Author:
Hong-Ping PAN
1
;
Jia-Zhen YANG
;
Xiang-Lan MO
;
Lu-Li LI
;
Zhen-Lu HUANG
;
Jing YE
;
Jin HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; pathology; Cell Death; drug effects; Cerebral Cortex; pathology; Female; Infarction, Middle Cerebral Artery; pathology; Isoflavones; pharmacology; Male; Neurons; drug effects; Neuroprotective Agents; pharmacology; Rats; Rats, Wistar; Vasodilator Agents; pharmacology
- From: China Journal of Chinese Materia Medica 2005;30(6):457-459
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protection of puerarin on the cerebral injury in the rats with acute local ischemia.
METHODRat was evaluated model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage toxylin and eosin((HE).
RESULTThe number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P < 0. 05). Similarly, the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats.
CONCLUSIONPuerarin can prevent the neuron from damage induced by acute cerebral ischemia.
