Effects of Naomaitai capsule on learning and memory and content of Ach in rat model produced by cerebral ischemia-reperfusion.
- Author:
Zheng WANG
1
;
Yun-Man LI
;
Xiao-Jian GONG
;
Jun LIN
;
Jie-Ming ZOU
Author Information
- Publication Type:Journal Article
- MeSH: Acetylcholine; metabolism; Animals; Brain Chemistry; Brain Ischemia; metabolism; Capsules; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Ginkgo biloba; chemistry; Learning; drug effects; Male; Memory; drug effects; Neuroprotective Agents; pharmacology; Panax; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Reperfusion Injury; metabolism; psychology
- From: China Journal of Chinese Materia Medica 2005;30(6):459-462
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Naomaitai capsule on the learning and memory abilities and the content of acetylcholine(Ach) in the brain tissue of the model rat.
METHODOne vascular dementia(VD) model was produced by occlusion of bilateral common carotid arteries in rats with following steps: ischemia 20 minutes-reperfusion 10 minutes-ischemia 20 minutes. The learning and memory abilities were tested by water maze. The other VD model was formed by 4-vessel occlusion-reperfusion injury in rats. The time of right reflect recovery and the content of Ach in the brain tissue were determined.
RESULTNaomaitai capsule can significantly improve the learning and memory abilities of the dementia rats( P < 0.05, P < 0.01), increase the content of Ach (P < 0.05, P < 0.01) and reduce the time of right reflect recovery(P < 0.01).
CONCLUSIONNaomaitai capsule can improve the learning and memory abilities by increasing the content of Ach of the VD rats.
