Study on pharmacokinetics of emodin in Rhizoma Polygontum Cuspidatum and its compound.
- Author:
Shu-Kun YAO
1
;
Ye JIANG
;
Xiao-Hua HAO
;
Hong-Ju LIU
;
Shao-Hao JANG
;
Wei-Na LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Area Under Curve; Capsules; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; chemistry; isolation & purification; Emodin; isolation & purification; pharmacokinetics; Female; Male; Plants, Medicinal; chemistry; Polygonum; chemistry; Rats; Rats, Sprague-Dawley; Rhizome; chemistry
- From: China Journal of Chinese Materia Medica 2005;30(6):463-465
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the difference in the pharmacokinetics of emodin in Zhiganning capsules and Rhizoma Polygontum Cuspidatum by nonaqueous RP-HPLC.
METHODThe rats were orally administered with the extraction of Rhizoma Polygontum Cuspidatum and Zhiganning capsules. After hydrolysis and extraction, the content of emodin in the plasma is determined by Nonaqueous RP-HPLC.
RESULTThe concentration-time profiles of emodin fit two-compartment model. The pharmacokinetics parameters including, t1/2alpha, AUC(0-infinity), CL(s) and C(max) of emodin in the group of Rhizoma Polygontum Cuspidatum were significantly different from these in the group of its compounds.
CONCLUSIONThere is a significant difference in pharmacokinetics of emodin between zhiganning capsules and the extraction of Rhizoma Polygontum Cuspidatum.
