Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action.
- Author:
Jing-Wei TIAN
1
;
Feng-Hua FU
;
Wang-Lin JIANG
;
Chao-Yun WANG
;
Fang SUN
;
Tai-Ping ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Benzofurans; isolation & purification; pharmacology; Blood Viscosity; drug effects; Brain Ischemia; blood; pathology; Dose-Response Relationship, Drug; Hematocrit; Infarction, Middle Cerebral Artery; blood; pathology; Ligusticum; chemistry; Male; Neuroprotective Agents; pharmacology; Plants, Medicinal; chemistry; Platelet Aggregation; drug effects; Rats; Rats, Wistar; Venous Thrombosis; prevention & control
- From: China Journal of Chinese Materia Medica 2005;30(6):466-468
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of ligusticum chuanxiong phthalides on cerebral ischemia in rats and its related mechanism of action.
METHODMiddle cerebral artery occlusion (MCAO) model, thrombosis formation, platelet aggregation and hemorrheological parameters were measured to evaluate the protective effect of ligusticum chuanxiong phthalides.
RESULTLigusticum chuanxiong phthalides could markedly decrease the infarct size and behavior deficits score, inhibit the thrombus formation and platelet aggregation, ameliorate hemorrheological parameters with a dose-dependent manner in rats.
CONCLUSIONLigusticum chuanxiong phthalides has protective effects on focal cerebral ischemia in rats, and its mechanism may be relevant to its inhibition of platelet-dependent thrombosis and amelioration of hemorrheological parameters.
