Inclusion constant of beta-CD and paeonol measured by phase solubility method.
- Author:
Xue-fen WU
1
;
Xiao-ke ZHENG
;
Hong-jian YAO
;
Na FEI
Author Information
- Publication Type:Journal Article
- MeSH: Acetophenones; administration & dosage; chemistry; isolation & purification; Drug Carriers; Drug Interactions; Drug Stability; Hot Temperature; Paeonia; chemistry; Plant Bark; chemistry; Plants, Medicinal; chemistry; Solubility; beta-Cyclodextrins
- From: China Journal of Chinese Materia Medica 2005;30(7):501-503
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEMeasure the thermal stability and the forming constant of inclusion complex for paeonol with beta-CD, and investigate interaction between beta-CD and paeonol,
METHODThe thermal stability investigated by using different thermal analysis. The forming constant was determined by using phase method.
RESULTComparing with melt temperature of paeonol, that of its inclusion complex increase about 220 degrees C. The solubility of paeonol increases with the increased concentration of beta-CD, the composing ratio and the inclusion constant of beta-CD-paeonol is respectively 1/1 and 27.42 mL x mg(-1).
CONCLUSIONInclusion constant is applied to research the stability of included drug in physiological condition.
