A correlate analysis of UV absorption spectra of compound danshen tablets from different manufactures.
- Author:
Zhi-jiang MO
1
;
Li-juan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Drug Combinations; Drugs, Chinese Herbal; administration & dosage; chemistry; isolation & purification; Plants, Medicinal; chemistry; Quality Control; Salvia miltiorrhiza; chemistry; Spectrophotometry, Ultraviolet; methods; Tablets
- From: China Journal of Chinese Materia Medica 2005;30(7):507-510
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of UV absorption spectrum for identification and quality control of compound Danshen tablets and pills.
METHODUV absorption spectra of compound Danshen tablets and pills, and other drugs were scanned using ultraviolet spectrophotometer (water as the solvent). Pearson's correlation coefficients (Pearson's R) were displayed in the correlations table obtained from SPSS correlate, and deltaR defined as the absolute value of the difference between Pearson's R and its mirror image in the table were used for measuring the spectral similarity between two drugs from different manufacturers.
RESULTRegarding compound Danshen tablets and pills, the spectral similarity between different batch drugs from same manufacturer was very high with Pearson's R = 0.995-0.9999, and the similarity between two manufactures was high with Pearson's R = 0.92-0.997 and deltaR < 0.02. Compared with the spectra of compound Danshen tablets and pills, the spectral similarity of the other drugs was low with Pearson's R = 0.25-0.98 and deltaR > 0.02.
CONCLUSIONThe results showed that UV absorption spectrum could be suitable for identification and quality control of compound Danshen tablets and pills.
