The effects of zhubi capsule on adjuvant arthritis in rats.
- Author:
Hui LI
1
;
Ya-hong JIN
;
Gui-dong YUAN
;
Su-fen WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Ankle Joint; pathology; Arthritis, Experimental; metabolism; pathology; Capsules; Cell Proliferation; drug effects; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; pharmacology; Interleukin-1; metabolism; Interleukin-6; metabolism; Male; Materia Medica; administration & dosage; pharmacology; Membrane Fluidity; drug effects; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Spleen; cytology; Synovial Membrane; drug effects
- From: China Journal of Chinese Materia Medica 2005;30(7):551-554
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the therapeutic effects and mechanisms of Zhubi capsule on adjuvant arthritis (AA) in rats.
METHODThe model of rat was induced by intradermal injection of CFA. The perimeter of ankle joint was measured at different time points. Con A-induced splencyte proliferation was examined by MIT assay and the expression of IL-1, IL-6 in synovium was determined by immunohistochemical method.
RESULTAfter the preventive administration of Zhubi capsule (5.2, 2.6, 1.3 g x kg x d(-1), x 25 d), it was found that Zhubi capsule significantly inhibited the primary and secondary ankle joint swelling. The increased Con A-induced splencyte proliferation reaction and the activated IL1, IL-6 expression of AA rat were suppressed by the treatment with Zhubi capsule.
CONCLUSIONZhubi capsule has a therapeutic effect on AA rats, and its mechanism is related to the immunoregulative function.
