The antitumor effects of total-flavonoid from Stellera chamaejasmel.
- Author:
Minn WANG
1
;
Zheng-Ping JIA
;
Jun MA
;
Bin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; administration & dosage; isolation & purification; pharmacology; Carcinoma, Hepatocellular; pathology; Cell Line, Tumor; Cell Proliferation; drug effects; Dose-Response Relationship, Drug; Female; Flavonoids; administration & dosage; isolation & purification; pharmacology; HL-60 Cells; Humans; Liver Neoplasms; pathology; Liver Neoplasms, Experimental; pathology; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Plants, Medicinal; chemistry; Sarcoma 180; pathology; Stomach Neoplasms; pathology; Thymelaeaceae; chemistry
- From: China Journal of Chinese Materia Medica 2005;30(8):603-606
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the antitumor effects of total-flavonoid from S. chamaejasmel.
METHODThe in vitro antitumor activity against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma BEL-7402 and leukemia HL-60, were determined by a MTT and clone formation assay. The in vivo antitumor activity was evaluated by the antitumor bioassay against transplanted mouse solid tumor S180 and H22.
RESULTThe total-flavonoid inhibited cell proliferation of human tumor cell lines, and its activities are higher than that of vincristine. The total-flavonoid also showed a lower acute toxicity and the strong antitumor activity against transplanted mouse solid tumor S180 and H22 in vivo showing a positive correlation with the concentration. The inhibitory rates at the dose of 0.10 g x kg(-1) ip against S180 and H22 are 45.64% and 47.59%, respectively.
CONCLUSIONThe total-flavonoid from S. chamaejasme has antitumor activities in vivo and in vitro.
