Experimental study on treatment of minimal change nephropathy with Lespedeza michx.
- Author:
Cai-Yun WANG
1
;
Hong-Zhu DENG
;
Hui LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Doxorubicin; Flavonoids; isolation & purification; pharmacology; Interleukin-8; blood; Kidney Glomerulus; pathology; Lespedeza; chemistry; Male; Malondialdehyde; blood; Nephrosis, Lipoid; blood; chemically induced; pathology; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; blood; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2005;30(8):614-617
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).
METHODThe rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.
RESULTLespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.
CONCLUSIONLespedeza Michx was effective on MCN.
