Effect of intestinal bacteria on metabolism of ophiopognin saponin D' in rats.
- Author:
Lan SHEN
1
;
De-Sheng XU
;
Yi FENG
;
Xiao LI
;
Xiao-Ru WU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Bacteria; metabolism; Biotransformation; Diosgenin; blood; metabolism; urine; Intestines; microbiology; Male; Ophiopogon; chemistry; Rats; Rats, Wistar; Saponins; administration & dosage; isolation & purification; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2005;30(8):618-620
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the metabolic transformation and the absorbed metabolites of ophiopognin saponin D' (OD') given orally in rats.
METHODThe contents of both original OD' and its metabolites were detected by means of HPLC-ELSD and the metabolites of OD' in blood and urine were measured by use of TLC and HPLC-MS in vivo.
RESULTOD' could be metabolized by intestinal bacteria in rats. The content of diosgenin, one of the metabolites, increased gradually as the time passed.
CONCLUSIONOD' can be metabolized in intestine of rat and its metabolite, diosgenin, was absorbed in blood of rat.
