Association of single nucleotide polymorphisms in TARC/CCL17 gene with Kawasaki disease and its clinical characteristics.
- Author:
Fan LIU
1
;
Yan DING
;
Wei YIN
Author Information
- Publication Type:Journal Article
- MeSH: Chemokine CCL17; genetics; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotype; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; genetics; Polymorphism, Single Nucleotide
- From: Chinese Journal of Contemporary Pediatrics 2015;17(7):668-671
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association of single nucleotide polymorphisms (SNPs, rs223895 and rs223899) in TARC/CCL17 gene with Kawasaki disease (KD) and its clinical characteristics in Han children from Central China.
METHODSA case-control study was performed on 218 children with KD and 248 normal control children. The genotypes of SNPs (rs223895 and rs223899) in TARC/CCL17 gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The association between the SNPs in TARC/CCL17 gene and the clinical characteristics of KD was assessed.
RESULTSThere were significant differences in the genotype (CC, CT, TT) and allele frequencies of SNP rs223895 between children with KD and controls (P<0.05), and C allele was a risk factor (OR=1.397). However, no significant differences were found between the two groups in the genotype and allele frequencies of SNP rs223899. Compared with those with other genotypes (CT+TT) of SNP rs223895, patients with CC genotype had significantly lower hemoglobin (Hb) and albumin (Alb) levels (P<0.05) and a significantly higher erythrocyte sedimentation rate (ESR) (P<0.05).
CONCLUSIONSThe SNP rs223895 in TARC/CCL17 gene is associated with the susceptibility to KD, and C allele is a risk factor. Moreover, SNP rs223895 may influence the levels of Hb, Alb, and ESR.
