Association between acanthosis nigricans and metabolic syndrome in children with obesity.
- Author:
Xin-Rui TAN
1
;
Mei-Zhen ZHANG
;
Min LI
;
Yan-Feng XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Acanthosis Nigricans; blood; etiology; Adiponectin; blood; Adolescent; Child; Cross-Sectional Studies; Female; Humans; Insulin Resistance; Leptin; blood; Logistic Models; Male; Metabolic Syndrome; blood; etiology; Obesity; complications
- From: Chinese Journal of Contemporary Pediatrics 2015;17(7):672-676
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate adipokines levels in obese children with acanthosis nigricans (AN) and to explore the relationship between AN and metabolic syndrome (MS).
METHODSA cross-sectional study was performed on 109 obese children and 47 age- and gender-matched normal controls. The obese children were divided into two groups with AN and without AN. Serum levels of adiponectin, leptin, TNF-α and retinol-binding protein 4 (RBP4) were measured using ELISA. Multiple logistic regression analysis was performed to estimate the association of clinical parameters with MS.
RESULTSWaist-hip ratio, systolic blood pressure, triglyceride, fasting insulin and insulin resistance index (HOMA-IR) were significantly higher in obese children with AN than in those without AN and normal controls (P<0.05). The obese children with AN and without AN had lower adiponectin levels than normal controls (P<0.05), on the contrary, the obese children with AN had higher leptin levels than those without AN and normal controls (P<0.05). Multiple logistic regression analysis revealed that AN (OR=3.469, 95%CI: 1.518-7.929) and BMI (OR=7.108, 95%CI: 2.359-21.416) were independent risk factors for MS.
CONCLUSIONSAs a visible marker of insulin resistance, AN is associated with abnormal adipokines secretion. Reducing the incidence of AN and losing weight may prevent obesity associated MS.