Changes in lymphocyte subsets and serum IFN-γ levels in children with toxoplasma infection.
- Author:
Hai-Jun ZHANG
1
;
Chun-Qin LU
;
Cai-Wen FANG
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Protozoan; blood; CD4-CD8 Ratio; Child, Preschool; Female; Humans; Immunoglobulin G; blood; Immunoglobulin M; blood; Infant; Interferon-gamma; blood; Lymphocyte Subsets; immunology; Male; Toxoplasma; immunology
- From: Chinese Journal of Contemporary Pediatrics 2015;17(7):687-691
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes and significance of lymphocyte sunsets and serum interferon-γ (IFN-γ) levels in children with toxoplasma infection.
METHODSThirty-four children who were newly diagnosed with toxoplasma infection (TOX-IgM+ group) between January 2011 and April 2014, 12 children who had ever been diagnosed with toxoplasma infection (TOX-IgG+ group), and 54 healthy children (control group) were enrolled. The percentages of CD4+, CD8+, CD19+ and NK cells in peripheral blood lymphocytes were detected by flow cytometry. Serum levels of IFN-γ were measured using ELISA.
RESULTSThe percentages of CD4+ cells and the CD4+/CD8+ ratio in the TOX-IgM+ group were significantly lower than in the TOX-IgG+ and control groups, while the percentages of CD8+ and NK cells and serum IFN-γ levels were significantly higher than in the other two groups (P<0.05). The TOX-IgG+ group had higher serum IFN-γ levels than the control group (P<0.05). There was a positive correlation between the percentage of CD8+ cells and serum IFN-γ levels in the TOX-IgM+ group (r=0.756; P<0.05).
CONCLUSIONSCD4+, CD8+ and NK cells may play important roles in the resistance against toxoplasma infection by promoting the secretion of cytokines.
