Changes in serum inflammatory factors in wheezing infants with community-acquired pneumonia.
- Author:
Zhi-Wei YU
1
;
Jun QIAN
;
Xiao-Hong GU
;
Xiao-Juan ZHANG
;
Jian-Rong PAN
;
Hui-Li JU
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; Community-Acquired Infections; immunology; Female; Humans; Infant; Interferon-gamma; blood; Interleukin-10; blood; Interleukin-4; blood; Male; Membrane Glycoproteins; blood; Pneumonia; immunology; Receptors, Immunologic; blood; Respiratory Sounds; immunology; Triggering Receptor Expressed on Myeloid Cells-1
- From: Chinese Journal of Contemporary Pediatrics 2015;17(8):815-818
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study whether infantile wheezing pneumonia has similar immune mechanisms to asthma by determining the levels of serum inflammatory factors in wheezing infants with community-acquired pneumonia (CAP).
METHODSForty-two infants with CAP but without wheezing, 47 infants with CAP and wheezing, and 30 healthy infants as a control were recruited in the study. The peripheral blood levels of C-reactive protein, procalcitonin, soluble triggering receptor expressed on myeloid cell-l, interferon-γ, interleukin-4, interleukin-10, and periostin were compared in the three groups.
RESULTSThe serum levels of procalcitonin, soluble triggering receptor expressed on myeloid cell-l, interleukin-4 and interleukin-10 in the two CAP groups were higher than in the control group (P<0.05). The ratio of interferon-γ/interleukin-4 in the wheezing pneumonia group was lower than in the non-wheezing pneumonia and control groups (P<0.05). The serum level of periostin in the wheezing pneumonia group was higher than in the non-wheezing pneumonia and control groups (P<0.05).
CONCLUSIONSThe unbalanced ratio of interferon-γ/interleukin-4 and airway eosinophilic inflammation in wheezing infants with pneumonia suggest infantile pneumonia with wheezing may has similar immune mechanisms to asthma.
