A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes.
- Author:
Xiao YANG
1
;
Xiao-Ai ZHANG
;
Zhi-Hao WU
;
Wei PENG
;
Li-Na ZHU
;
Yan WANG
Author Information
- Publication Type:Journal Article
- MeSH: 2',5'-Oligoadenylate Synthetase; genetics; Adult; Case-Control Studies; Female; Fetal Membranes, Premature Rupture; genetics; Genetic Predisposition to Disease; Humans; Infant, Newborn; Male; Polymorphism, Single Nucleotide; Premature Birth; genetics
- From: Chinese Journal of Contemporary Pediatrics 2015;17(9):898-902
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the genetic polymorphism of 2',5'-oligoadenylate synthetase 1 (OAS1) and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM).
METHODSThe case-control study consisted of 599 preterm infants including 171 cases of PPROM, and 673 full-term infants without maternal histories of SPTB and PPROM as controls. The single nucleotide polymorphism (SNP) at OAS1 intron 5, rs10774671, was analyzed by polymerase chain reaction-restriction fragment length polymorphism.
RESULTSNo significant differences were observed between the case and control groups in the frequencies of genotypes (AA, GA, and GG) and alleles (A and G) of OAS1 rs10774671. When the case group was divided into two subgroups with or without PPROM, no significant differences in the genotype and allele frequencies were found between each subgroup and the control group. When the case group was divided into three subgroups with different gestational ages at SPTB, no significant differences in the genotype and allele frequencies were detected between each subgroup and the control group.
CONCLUSIONSNo association is identified between OAS1 SNP and susceptibility to SPTB and PPROM.
