Risk factors for coronary artery lesions secondary to Kawasaki disease in children.
- Author:
Yong-Chao DENG
1
;
Xun WANG
;
Xi-Chun TANG
;
Cai-Zhi HUANG
;
Juan YANG
;
Li-Ya MO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Calcitonin; blood; Calcitonin Gene-Related Peptide; Child; Child, Preschool; Coronary Artery Disease; etiology; Female; Humans; Immunoglobulins, Intravenous; therapeutic use; Infant; Male; Mucocutaneous Lymph Node Syndrome; complications; Protein Precursors; blood; Risk Factors
- From: Chinese Journal of Contemporary Pediatrics 2015;17(9):927-931
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the risk factors for coronary artery lesions (CAL) secondary to Kawasaki disease (KD) in children.
METHODSThe medical data of 895 children with KD were retrospectively reviewed. The patients were classified into two groups according to the presence of CAL: CAL (n=284) and control (n=611). The clinical and laboratory indices were compared between the two groups. The risk factors for the development of CAL in children with KD were identified by multiple logistic regression analysis.
RESULTSMale gender (OR=1.712), occurrence of non-CAL complications (OR=2.028), atypical KD (OR=3.655), intravenous immunoglobulin (IVIG) resistance (OR=2.912), more than 5 days of fever duration before IVIG treatment (OR=1.350), and increased serum procalcitonin (PCT) level (OR=1.068) were the independent risk factors for the development of CAL in children with KD (P<0.05), whereas increased serum albumin (Alb) level was a protective factor (OR=0.931, P<0.05). The areas under the receiver operating characteristic curve of serum PCT and ALB for prediction of the development of CAL in children with KD were 0.631 and 0.558, respectively.
CONCLUSIONSMale gender, atypical KD, occurrence of other non-CAL complications, long duration of fever and IVIG resistance are associated with an increased risk for CAL in children with KD. Serum PCT and ALB have little value in the prediction of CAL in children with KD.
