Risk factors for multidrug-resistant Klebsiella pneumoniae sepsis in children.
- Author:
Chao CHENG
1
;
Ye-Xin LIN
;
Jiu-Jun LI
;
Zhi-Jie ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Bacteremia; drug therapy; etiology; Case-Control Studies; Child; Child, Preschool; Drug Resistance, Multiple, Bacterial; Female; Humans; Infant; Klebsiella Infections; drug therapy; Klebsiella pneumoniae; drug effects; Logistic Models; Male; Retrospective Studies; Risk Factors
- From: Chinese Journal of Contemporary Pediatrics 2015;17(9):932-936
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the risk factors for sepsis caused by multidrug-resistant Klebsiella pneumonia (MDR-KP) and to provide a reference for the prevention of MDR-KP sepsis and rational use of antibiotics.
METHODSA retrospective case-control study of 41 children with MDR-KP sepsis (case group) and 53 pediatric patients without MDR-KP sepsis (control group) between March 2010 and Febrary 2014 was conducted. Multiple logistic regression analysis was performed to estimate the independent risk factors for MDR-KP sepsis.
RESULTSCompared with the control group, the case group had a longer length of stay in the PICU before infection (P<0.05), more prolonged duration of mechanical ventilation before infection (P<0.05), a larger total number of days of mechanical ventilation (P<0.05), more days of antibiotic use before infection (P<0.05), more types of antibiotics used before infection (P<0.05), and a higher mortality (P<0.05). The logistic regression analysis showed that more types of antibiotics used before infection and use of third-generation cephalosporin and carbapenems were independent risk factors for MDR-KP sepsis (P<0.05).
CONCLUSIONSRational use of antibiotics is an effective measure to prevent MDR-KP sepsis.
