Research advances in persistent pulmonary hypertension of the newborn secondary to congenital diaphragmatic hernia.
- Author:
Bin XIAO
1
;
Min LIU
;
Chang XU
Author Information
1. Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. xcxcxc52229081@163.com.
- Publication Type:Journal Article
- MeSH:
Hernias, Diaphragmatic, Congenital;
complications;
Humans;
Infant, Newborn;
Persistent Fetal Circulation Syndrome;
etiology;
therapy
- From:
Chinese Journal of Contemporary Pediatrics
2015;17(9):1013-1019
- CountryChina
- Language:Chinese
-
Abstract:
Persistent pulmonary hypertension of the newborn (PPHN) secondary to congenital diaphragmatic hernia (CDH) is one of the main reasons for high mortality of the newborn and a factor that leads to respiratory and circulatory failure in newborns with CDH. PPHN secondary to CDH is severe and difficult to treat, with poor prognosis. Therefore, prenatal intervention aims for preventing the pathological process of CDH, especially the etiological treatment for impeding the development of PPHN, has become a research focus. Given unknown causes and poor outcomes of PPHN, this article summarizes the research advances in pathogenesis and treatment of PPHN secondary to CDH based on related studies so as to provide a reference for relevant studies and clinical treatment.
