Analysis of HLA matching probability in Guangzhou Cord Blood Bank.
- Author:
Yan LI
1
;
Can LIAO
;
Xue-Wei TANG
;
Xing-Mei XIE
;
Yi-Ning HUANG
;
Jie-Ying WU
;
Xin YANG
Author Information
1. Guangzhou Cord Blood Bank, Guangzhou Maternal and Neonatal Hospital, Guangzhou 510180, China. gzcord@163.net
- Publication Type:Journal Article
- MeSH:
Blood Banks;
Body Weight;
Fetal Blood;
transplantation;
Hematopoietic Stem Cell Transplantation;
methods;
Histocompatibility Testing;
Humans;
Probability
- From:
Journal of Experimental Hematology
2003;11(4):424-428
- CountryChina
- Language:Chinese
-
Abstract:
The HLA matching results for 1 060 patients searching donors within 3 000 units of umbilical cord blood in Guangzhou Cord Blood Bank from 1998 to 2002 were analyzed. There were 119 (11.23%) and 992 (93.58%) patients found 6/6 and more than 4/6 of HLA matched loci of unrelated cord blood donors respectively. 61.29% of probability in all patients could find one or more cord blood with 4/6 or more matched loci and total nucleated cell (TNC) dose of >or= 3.7 x 10(7)/kg. The highest mean body weight in these supplied patients was 79 kg. The probability was 89.79% for those patients with TNC dose of >or= 2.0 x 10(7)/kg and >or= 4/6 of HLA loci matched. In these patients, the highest weight was 175 kg. In conclusion, a cord blood bank with 3 000 units or more of cord blood in stock shows a high probability of HLA matching and can meet the requirement of TNC >or= 3.7 x 10(7)/kg dose in child and part of adult patients. The umbilical cord blood is a good alternative stem cell source for all patients including adults.
