Clinical analysis of retinoic acid syndrome developed in 11 patients with acute promyelocytic leukemia.
- Author:
Zhi WANG
1
;
Jin-Ping FENG
;
Miao-Wang HAO
;
Yin-Suo ZHENG
;
Yu-Ping TIAN
;
Ya-Zhou YAO
;
Xiu-Qin BAI
Author Information
1. Department of Hematology, Shanxi Baoji Central Hospital, Baoji 721008, China. wz12888@sohu.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Child;
Dyspnea;
etiology;
Female;
Fever;
etiology;
Humans;
Hydrothorax;
etiology;
Leukemia, Promyelocytic, Acute;
drug therapy;
Male;
Middle Aged;
Syndrome;
Tretinoin;
adverse effects
- From:
Journal of Experimental Hematology
2003;11(5):469-471
- CountryChina
- Language:Chinese
-
Abstract:
To explore the clinical features, risk factors an d treatment of retinoic acid syndrome (RAS) in patients with acute promyelocytic leukemia (APL) treated with retinoic acid, the clinical and laboratory data of 11 APL patients with RAS were retrospectively analysed. The results showed that earlier and more common symptoms of RAS were successively dyspnea (11/11), fever (10/11) and hydrothorax (6/11). Higher WBC count (> or = 15.0 x 10(9)/L) in the course of treatment of all-trans retinoic acid susceptible to develop RAS (9/11). The RAS patients were treated with dexamethasone without discontinuing the treatment of retinoic acid, complete remission was achieved in 10 cases and one patient died from disseminated intravascular coagulation. It is concluded that the identification and dexamethasone treatment of RAS in earlier period are extremely important for obtaining better clinical curative effect, and it does not influence therapeutic effect of continuing application of retinoic acid.
